![]() ![]() 7, 8 In humans, tryptophan has relatively low tissue storage 9 and the overall tryptophan concentration in the body is the lowest among all amino acids, 10, 11 although only small amounts are necessary for general healthy nutrition. 3 – 5 For all amino acids, including L-tryptophan, only the L isomer is used in protein synthesis 6 and can pass across the blood-brain barrier. amino acids that cannot be synthesized in the human body and must be supplied by the diet). tryptophan) is one of eight essential amino acids (i.e. Hopkins and Cole 1 discovered tryptophan in the early 1900s after isolating it from casein protein, and Ellinger and Flamand 2 determined its molecular structure a short time later. Furthermore, clinical trials have provided some initial evidence of L-tryptophan’s efficacy for treatment of psychiatric disorders, particularly when used in combination with other therapeutic agents. As the sole precursor of serotonin, experimental research has shown that L-tryptophan’s role in brain serotonin synthesis is an important factor involved in mood, behavior, and cognition. The ability to change the rates of serotonin synthesis in the brain by manipulating concentrations of serum tryptophan is the foundation of much research. With emphasis on L-tryptophan’s role in synthesis of brain serotonin, details are provided on the research uses of L-tryptophan, particularly L-tryptophan depletion, and on clinical trials that have been conducted using L-tryptophan supplementation. This review provides a brief overview of the role of L-tryptophan in protein synthesis and a number of other metabolic functions. If making a post asking for the easy way out on learning about a compound, most likely you will just be linked to as it is less work for us.īe sure to read the /r/fitness/wiki/faq if your post is about diet/fat loss/gaining muscle.An essential component of the human diet, L-tryptophan is critical in a number of metabolic functions and has been widely used in numerous research and clinical trials. Prior to posting, please review the compound on a science-based website like rather than asking for vague 'educate me on.' posts. If you make a claim about a supplement and get called out on it be prepared to either cite your source or logically defend your stance.īroscience is accepted as it can lead to new theories and discoveries, but it must be clearly stated it is broscience or 'feel'. Although subjective, any posts in which there is suspicion of being affiliated with a supplement company may result in banning after various considerations (contribution to community, relevance to discussion, unforeseen context, etc.) are looked at. It is acceptable to talk about which companies and suppliers you like but unacceptable to spam for them. (Basically, talk with us about something don't be a pretentious anti-supplement douche)Īnything talking about supplement companies is a grey area which must be ventured cautiously. Repeated offenses or notably excessive offenses are subject to banning. However, discussions or rants declaring a supplement or supplement regimen useless based on emotion and naturalistic fallacy rather than science or logical caution are subject to moderation. Discussion on the relative pros and cons for supplementation are accepted and encouraged. This is a subreddit designed for supplements, so obviously most users will be biased for supplements. This is to help reduce spamming in the subreddit if you wish to discuss your brand name supplement, simply list the ingredients and dosages, not the brand name. Posts made with brand name products as the topic of discussion (rather than the molecule(s) in question) may be removed.General Rules and Guidelines or /r/supplements: ![]() Slightly more IMPORTANT: In regards to illegal/dangerous drugs and how to approach their mention in this subreddit IMPORTANT: For those with blogs/channels dealing with supplements or members of companies which sell nutritional supplements. A subreddit designed for discussion of supplements and nutraceuticals for health, performance, or any intended (or not intended) purpose.
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